2018


Högel P, Götz A, Kuhne F, Ebert M, Stelzer W, Rand KD, Scharnagl C, Langosch D.

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.

Biochemistry. 2018 Feb 1. doi: 10.1021/acs.biochem.7b01197. [Epub ahead of print]

PMID: 29389107

Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld Th, Lichtenthaler SF (2018).

Non-cell-autonomous function of DR6 in Schwann cell proliferation.

EMBO J. in Press

 

Fukumori, A., Trambauer, J., Feilen, L.P. & Steiner, H. (2018)

Photoaffinitätsmarkierung: Identifizierung von Substratbindestellen in der γ-Sekretase.

BIOspektrum, 1, 34-36.

 

Kronenberg-Versteeg, D., Eichmann, M., Russell, M.A., de Ru, A., Hehn, B., Yusuf, N., van Veelen, P.A., Richardson, S.J., Morgan, N.G., Lemberg, M.K., Peakman, M. (2018)

Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 Diabetes.

Diabetes 2018 Jan; db170021. https://doi.org/10.2337/db17-0021

 


2017


Mentrup T, Loock AC, Fluhrer R, Schröder B.

Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?

Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2169-2182. doi: 10.1016/j.bbamcr.2017.06.007. Epub 2017 Jun 15. Review. PMID: 28624439

 

Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C.

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

EMBO Mol Med. 2017 Oct;9(10):1356-1365. doi: 10.15252/emmm.201707672. PMID: 28855300 Free PMC Article

 

Mentrup T, Fluhrer R, Schröder B.

Latest emerging functions of SPP/SPPL intramembrane proteases.

Eur J Cell Biol. 2017 Aug;96(5):372-382. doi: 10.1016/j.ejcb.2017.03.002. Epub 2017 Mar 16. Review. PMID: 28366434

 

Jules F, Sauvageau E, Dumaresq-Doiron K, Mazzaferri J, Haug-Kröper M, Fluhrer R, Costantino S, Lefrancois S.

Exp Cell Res. 2017 Aug 1;357(1):40-50. doi: 10.1016/j.yexcr.2017.04.024. Epub 2017 Apr 22. PMID: 28442266

 

Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, Mueggler T, Arzberger T, Knuesel I, Rominger A, Haass C.

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

EMBO J. 2017 Jul 3;36(13):1837-1853. doi: 10.15252/embj.201796516. Epub 2017 May 30. PMID: 28559417

 

Julius A, Laur L, Schanzenbach C, Langosch D.

BLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE.

J Mol Biol. 2017 Jun 2;429(11):1630-1637. doi: 10.1016/j.jmb.2017.04.003. Epub 2017 Apr 19. PMID: 28432015

 

Scilabra SD, Yamamoto K, Pigoni M, Sakamoto K, Müller SA, Papadopoulou A, Lichtenthaler SF, Troeberg L, Nagase H, Kadomatsu K.

Langosch D, Steiner H.

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Biol Chem. 2017 Apr 1;398(4):441-453. doi: 10.1515/hsz-2016-0269. Review. PMID: 27845877

 

Schanzenbach C, Schmidt FC, Breckner P, Teese MG, Langosch D.

Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions.

Sci Rep. 2017 Mar 7;7:43476. doi: 10.1038/srep43476. PMID: 28266525 Free PMC Article

 

Serdaroglu A, Müller SA, Schepers U, Bräse S, Weichert W, Lichtenthaler SF, Kuhn PH.

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

Proteomics. 2017 Mar;17(5). doi: 10.1002/pmic.201600423. Epub 2017 Jan 31. PMID: 27991726

 

Baranger K, Bonnet AE, Girard SD, Paumier JM, García-González L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS, Checler F, Khrestchatisky M, Rivera S.

MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro.

Front Mol Neurosci. 2017 Jan 10;9:163. doi: 10.3389/fnmol.2016.00163. eCollection 2016. PMID: 28119565 Free PMC Article

 

Trambauer J, Fukumori A, Kretner B, Steiner H.

Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators.

Methods Enzymol. 2017;584:157-183. doi: 10.1016/bs.mie.2016.10.013. Epub 2016 Dec 1. PMID: 28065262

 


2016


Fleck, D., M. Voss, B. Brankatschk, C. Giudici, H. Hampel, B. Schwenk, D. Edbauer, A. Fukumori, H.

Steiner, E. Kremmer, M. Haug-Kroper, M. J. Rossner, R. Fluhrer, M. Willem & C. Haass (2016)

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem, 291, 318-33 10.1074/jbc.M115.697995.

Müller SA, Scilabra SD, Lichtenthaler SF.

Front Mol Neurosci. 2016 Oct 13;9:96. eCollection 2016. Review. PMID: 27790089 Free PMC Article

 

Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF.

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Mol Neurodegener. 2016 Oct 5;11(1):67. PMID: 27716410 Free PMC Article

 

Stelzer, W., Scharnagl, C., Leurs, U., Rand, K.D., Langosch, D. (2016):

"The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region"

ChemistrySelect, 1: 4403-4407. DOI: 10.1002/slct.201600951 (submitted PDF version, Supporting Information)

 

Kretner, B., Trambauer, J., Fukumori, A., Mielke, J., Kuhn, P-H., Kremmer, E., Giese, A. , Lichtenthaler, S.F., Haass, C., Arzberger, T., Steiner, H. (2016):

"Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease."

EMBO Molecular Medicine. 2016. e201505952.

 

Hüttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schröder B.

Biochem J. 2016 May 15;473(10):1405-22. doi: 10.1042/BCJ20160156. Epub 2016 Mar 17. PMID: 26987812

 

Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF.

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.

Elife. 2016 Jan 23;5. pii: e12748. doi: 10.7554/eLife.12748. PMID: 26802628 Free PMC Article

 


2015


Winkler, E., Julius, A., Steiner, H., Langosch, D. (2015):

"Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase."
Biochemistry. 2015 Oct 13;54(40):6149-52

 

Langosch, D., Scharnagl, C.,  Steiner, H., Lemberg, M.K. (2015):

"Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics."
Trends Biochem Sci. 2015 Jun;40(6):318-27