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The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.
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NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
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EMBO Mol Med. 2019 Apr;11(4). pii: e9695. doi: 10.15252/emmm.201809695. PMID: 30833305
Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig AO, Happ K, Gijbels M, Gradtke AC, Rabe B, Fukumori A, Steiner H, Tholey A, Fluhrer R, Donners M, Schröder B.
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Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1. PMID: 30926830
Structural Modeling of γ-Secretase Aβ n Complex Formation and Substrate Processing.
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The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B.
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