Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases

Fleck, D., M. Voss, B. Brankatschk, C. Giudici, H. Hampel, B. Schwenk, D. Edbauer, A. Fukumori, H.

Steiner, E. Kremmer, M. Haug-Kroper, M. J. Rossner, R. Fluhrer, M. Willem & C. Haass (2016)

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem, 291, 318-33 10.1074/jbc.M115.697995.

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Biol Chem. 2016 Nov 15. pii: /j/bchm.just-accepted/hsz-2016-0269/hsz-2016-0269.xml. doi: 10.1515/hsz-2016-0269. [Epub ahead of print]

Stelzer, W., Scharnagl, C., Leurs, U., Rand, K.D., Langosch, D. (2016):

"The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region"

ChemistrySelect, 1: 4403-4407. DOI: 10.1002/slct.201600951 (submitted PDF version, Supporting Information)

Kretner, B., Trambauer, J., Fukumori, A., Mielke, J., Kuhn, P-H., Kremmer, E., Giese, A. , Lichtenthaler, S.F., Haass, C., Arzberger, T., Steiner, H. (2016):

"Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease."

EMBO Molecular Medicine. 2016. e201505952.

Fukumori, A. & Steiner, H. (2016):

"Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping."

EMBO J. 2016 May 23. pii: e201694151.

Winkler, E., Julius, A., Steiner, H., Langosch, D. (2015):

"Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase."
Biochemistry. 2015 Oct 13;54(40):6149-52

Langosch, D., Scharnagl, C.,  Steiner, H., Lemberg, M.K. (2015):

"Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics."
Trends Biochem Sci. 2015 Jun;40(6):318-27