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Uncovering the Binding Mode of γ -Secretase Inhibitors.
Hitzenberger M, Zacharias M.
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Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.
Hsia HE, Tüshaus J, Brummer T, Zheng Y, Scilabra SD, Lichtenthaler SF.
Cell Mol Life Sci. 2019 Jun 24. doi: 10.1007/s00018-019-03173-7. [Epub ahead of print] Review. PMID: 31236626
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C.
Cell Mol Life Sci. 2019 Jun 17. doi: 10.1007/s00018-019-03184-4. [Epub ahead of print] PMID: 31209506
Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.
Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H.
Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3. PMID: 31130234
NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
Brummer T, Müller SA, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, Endres K, Lichtenthaler SF.
EMBO Mol Med. 2019 Apr;11(4). pii: e9695. doi: 10.15252/emmm.201809695. PMID: 30833305
Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig AO, Happ K, Gijbels M, Gradtke AC, Rabe B, Fukumori A, Steiner H, Tholey A, Fluhrer R, Donners M, Schröder B.
J Exp Med. 2019 Apr 1;216(4):807-830. doi: 10.1084/jem.20171438. Epub 2019 Feb 28. PMID: 30819724
Götz A, Högel P, Silber M, Chaitoglou I, Luy B, Muhle-Goll C, Scharnagl C, Langosch D.
Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1. PMID: 30926830
Structural Modeling of γ-Secretase Aβ n Complex Formation and Substrate Processing.
Hitzenberger M, Zacharias M.
ACS Chem Neurosci. 2019 Mar 20;10(3):1826-1840. doi: 10.1021/acschemneuro.8b00725. Epub 2019 Jan 30. PMID: 30638370
Yücel SS, Stelzer W, Lorenzoni A, Wozny M, Langosch D, Lemberg MK.
Cell Rep. 2019 Mar 12;26(11):3087-3099.e11. doi: 10.1016/j.celrep.2019.02.057. PMID:30865896
Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R.
EMBO Rep. 2019 Feb 7. pii: e46451. doi: 10.15252/embr.201846451. [Epub ahead of print] PMID: 30733281
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B.
EMBO Rep. 2019 Feb 7. pii: e46449. doi: 10.15252/embr.201846449. [Epub ahead of print]
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C.
Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7. PMID: 30617257
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Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding
Manuel Hitzenberger, Martin Zacharias
Front Chem. 2018; 6: 640. Published online 2019 Jan 4. doi: 10.3389/fchem.2018.00640 PMCID: PMC6328467
Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
Harald Steiner, Akio Fukumori, Shinji Tagami and Masayasu Okochi (2018).
Cell Stress 2(11): 292-310. doi: 10.15698/cst2018.11.162
Shedding of BAFF/APRIL Receptors Controls B Cells.
Meinl E, Thaler FS, Lichtenthaler SF.
Trends Immunol. 2018 Sep;39(9):673-676. doi: 10.1016/j.it.2018.07.002. Epub 2018 Jul 30.
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Mol Cell Proteomics. 2018.
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CADASIL brain vessels show a HTRA1 loss-of-function Profile.
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Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.
Högel P, Götz A, Kuhne F, Ebert M, Stelzer W, Rand KD, Scharnagl C, Langosch D.
Non-cell-autonomous function of DR6 in Schwann cell Proliferation.
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Photoaffinitätsmarkierung: Identifizierung von Substratbindestellen in der γ-Sekretase.
Fukumori, A., Trambauer, J., Feilen, L.P. & Steiner, H. (2018)
BIOspektrum, 2018, 1, 34-36.
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Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.
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Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
Mentrup T, Loock AC, Fluhrer R, Schröder B.
Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2169-2182.
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Latest emerging functions of SPP/SPPL intramembrane proteases.
Mentrup T, Fluhrer R, Schröder B.
Eur J Cell Biol. 2017 Aug;96(5):372-382. doi: 10.1016/j.ejcb.2017.03.002. Epub 2017 Mar 16. Review. PMID: 28366434
CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein.
Jules F, Sauvageau E, Dumaresq-Doiron K, Mazzaferri J, Haug-Kröper M, Fluhrer R, Costantino S, Lefrancois S.
Exp Cell Res. 2017 Aug 1;357(1):40-50. doi: 10.1016/j.yexcr.2017.04.024. Epub 2017 Apr 22. PMID: 28442266
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Julius A, Laur L, Schanzenbach C, Langosch D.
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Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.
Langosch D, Steiner H.
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Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators.
Trambauer J, Fukumori A, Kretner B, Steiner H.
Methods Enzymol. 2017;584:157-183. doi: 10.1016/bs.mie.2016.10.013. Epub 2016 Dec 1. PMID: 28065262
Proteomic Substrate Identification for Membrane Proteases in the Brain.
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Elife. 2016 Jan 23;5. pii: e12748. doi: 10.7554/eLife.12748. PMID: 26802628 Free PMC Article
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Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.
Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.
J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16. PMID: 26574544 Free PMC Article
"Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase."
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Biochemistry. 2015 Oct 13;54(40):6149-52
"Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics."
Langosch, D., Scharnagl, C., Steiner, H.,
Lemberg, M.K. (2015)
Trends Biochem Sci. 2015 Jun;40(6):318-27