2016


Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases

Fleck, D., M. Voss, B. Brankatschk, C. Giudici, H. Hampel, B. Schwenk, D. Edbauer, A. Fukumori, H.

Steiner, E. Kremmer, M. Haug-Kroper, M. J. Rossner, R. Fluhrer, M. Willem & C. Haass (2016)

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem, 291, 318-33 10.1074/jbc.M115.697995.

Langosch, D. & Steiner, H. (2016)

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Biol Chem. 2016 Nov 15. pii: /j/bchm.just-accepted/hsz-2016-0269/hsz-2016-0269.xml. doi: 10.1515/hsz-2016-0269. [Epub ahead of print]

Stelzer, W., Scharnagl, C., Leurs, U., Rand, K.D., Langosch, D. (2016):

"The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region"

ChemistrySelect, 1: 4403-4407. DOI: 10.1002/slct.201600951 (submitted PDF version, Supporting Information)

 

Kretner, B., Trambauer, J., Fukumori, A., Mielke, J., Kuhn, P-H., Kremmer, E., Giese, A. , Lichtenthaler, S.F., Haass, C., Arzberger, T., Steiner, H. (2016):

"Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease."

EMBO Molecular Medicine. 2016. e201505952.

 


2015


Winkler, E., Julius, A., Steiner, H., Langosch, D. (2015):

"Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase."
Biochemistry. 2015 Oct 13;54(40):6149-52

 

Langosch, D., Scharnagl, C.,  Steiner, H., Lemberg, M.K. (2015):

"Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics."
Trends Biochem Sci. 2015 Jun;40(6):318-27