DFG Research Unit FOR 2290


Understanding Intramembrane Proteolysis

Defining the Repertoire of Substrates

and their Molecular Architectures



Project P1:Substrate Recognition and Cleavage by the Mitochondrial Rhomboid Protease PARL

Prof. Marius Lemberg



Project P2

Substrate Portfolio of the Signal Peptide Peptidase-like 2 (SPPL2) family

 

Prof. Regina Fluhrer


Project P3

Identification and mechanistic characterization of a new class of γ-secretase substrates and non-substrates with short extracellular domains

 

Prof. Stefan Lichtenthaler

Project P4

Substrate Recognition and Cleavage by γ-Secretase

 

Prof. Harald Steiner


Project P5

The Conformational Flexibility of Transmembrane Helices in Substrate Recognition and Cleavage

 

Prof. Dieter Langosch


Project P6

Role of transmembrane domain interactions for g-secretase substrate recognition using the TREM2/DAP12 complex

 

Prof. Christian Haass

Project P7

 

Dynamics of

Substrate-Protease

Interactions

Prof. Martin Zacharias

Dr. Christina Scharnagl


Project P8

Investigation of Molecular Dynamics of Substrate

Transmembrane α-Helices by Solution and Solid-State NMR Spectroscopy

Prof. Burkhard Luy

Prof. Daniel Huster


 

Title

PI

Discipline

Affiliation

P1

Substrate Recognition

and Cleavage by the Mitochondrial Rhomboid Protease PARL

Marius Lemberg

Cell biology,

biochemistry

Uni Heidelberg

P2

Substrate Recognition

and Processing by Signal Peptide Peptidase-like 2 (SPPL2) Family

Regina Fluhrer

Cell biology,

biochemistry

LMU München

P3

Mechanistic Characterization of Substrate Recognition by γ-Secretase

Stefan Lichtenthaler

Proteomics,

biochemistry

DZNE München

P4

Substrate Recruitment

and Cleavage by

γ-Secretase

Harald Steiner

Biochemistry

LMU München

P5

Substrate Transmembrane Helices: Conformational Flexibility and Recognition by an Enzyme

Dieter Langosch

Biochemistry

TU München

P6

Functional Role of Transmembrane Domain Interactions and Intramembrane Cleavage

of Microglial Innate Immunity Receptors

Christian Haass

Biochemistry

LMU München

P7

Dynamics of

Substrate-Protease

Interactions

Martin Zacharias

 

Christina Scharnagl

in silico modeling

TU München

P8

Investigation of the Molecular Dynamics of Substrate Transmembrane α-Helices by Solution and Solid-State NMR Spectroscopy

 

Claudia Muhle-Goll

 

Daniel Huster

 

 

liquid-state NMR

 

solid-state NMR

 

 

KIT Karlsruhe

 

Uni Leipzig

 

P9

Proteomic Platform

Stefan Lichtenthaler

Proteomics

DZNE München