DFG Research Unit FOR 2290


Speaker:

Project P5: The Conformational Flexibility of Transmembrane Helices in Substrate Recognition and Cleavage

Deputy speaker:

Project P4: Substrate Recognition and Cleavage by γ-Secretase



Project P1:

Substrate Recognition and Cleavage by the Mitochondrial Rhomboid Protease PARL

Project P2:

Substrate Portfolio of the Signal Peptide Peptidase-like 2 (SPPL2) family

Project P3:

Identification and mechanistic characterization of a new class of γ-secretase substrates and non-substrates with short extracellular domains

Project P9: Proteomic Platform

Project P6:

Role of transmembrane domain interactions for g-secretase substrate recognition using the TREM2/DAP12 complex



Project P7:

Dynamics of Substrate-Protease Interactions

Project P8:

Investigation of Molecular Dynamics of Substrate Transmembrane α-Helices by Solution and Solid-State NMR Spectroscopy




Research Unit FOR 2290