DFG Research Unit FOR 2290
Speaker:
Project P5: The Conformational Flexibility of Transmembrane Helices in Substrate Recognition and Cleavage
Deputy speaker:
Project P4: Substrate Recognition and Cleavage by γ-Secretase
Substrate Recognition and Cleavage by the Mitochondrial Rhomboid Protease PARL
Substrate Portfolio of the Signal Peptide Peptidase-like 2 (SPPL2) family
Identification and mechanistic characterization of a new class of γ-secretase substrates and non-substrates with short extracellular domains
Proteomic Platform
Role of transmembrane domain interactions for g-secretase substrate recognition using the TREM2/DAP12 complex
Dynamics of Substrate-Protease Interactions
Investigation of Molecular Dynamics of Substrate Transmembrane α-Helices by Solution and Solid-State NMR Spectroscopy