DFG Research Unit FOR 2290


Speaker:

Project P5: The Conformational Flexibility of Transmembrane Helices in Substrate Recognition and Cleavage

Deputy speaker:

Project P4: Substrate Recognition and Cleavage by γ-Secretase



Substrate Recognition and Cleavage by the Mitochondrial Rhomboid Protease PARL

Substrate Portfolio of the Signal Peptide Peptidase-like 2 (SPPL2) family

Identification and mechanistic characterization of a new class of γ-secretase substrates and non-substrates with short extracellular domains

Proteomic Platform

Role of transmembrane domain interactions for g-secretase substrate recognition using the TREM2/DAP12 complex



Dynamics of Substrate-Protease Interactions

Investigation of Molecular Dynamics of Substrate Transmembrane α-Helices by Solution and Solid-State NMR Spectroscopy




Research Unit FOR 2290