Protein Recognition and Processing
in the Membrane
2nd International Meeting 2022
of the DFG research unit FOR2290
'Understanding Intramembrane Proteolysis'
May 4-6, 2022, Munich, Germany
Wednesday, May 4, 2022:
13:00 Check-in & Registration
14:00 Welcome Notes: Dieter Langosch
14:15 Keynote Lecture
Chair: Harald Steiner
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14:15 |
Lucía Chávez‐Gutiérrez: Decoding γ-Secretases and their Roles in Alzheimer’s Pathogenesis |
15:00 - 16:00 Session 1: Physiology of Regulated Intramembrane Proteolysis I
Chair: Walter Stöcker
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15:00 |
Christian Haass / Kai Schlepckow: Identification of TREM2 Cleavage Sites and their Role in Alzheimer’s Disease
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15:20 |
Stefan Rose-John: ADAM17 in Autoimmunity and Cancer
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15:40 |
Irit Sagi: Newly Discovered Natural Anti-MT1MMP Human Antibodies Derived from Cancer Patients |
16:00-16:30 Coffee break
16:30 - 18:00 Session 2: Physiology of Regulated Intramembrane Proteolysis II
Chair: Regina Fluhrer
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16:30 |
Stefan Lichtenthaler: Naturally Short Substrates of γ-Secretase
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16:50 |
Wim Annaert: On the Origin of Endolysosomal Dysfunction in Presenilin/γ-Secretase Deficient Cells
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17:10 |
Bernd Schröder: Signal Peptide Peptidase-Like Intramembrane Proteases – from Immune Cells to Metabolic Regulation |
17:30 Poster Lightning Talks
19:00 Dinner
20:30 Poster Session I (No. 1 - 14; presenters last name A-K)
Thursday, May 5, 2022:
09:00 - 10:35 Session 3: Mechanisms in Intramembrane Proteolysis I
Chair: Daniel Huster
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9:00 |
Regina Fluhrer: Determinants of SPP/SPPL Substrates
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9:20 |
Kvido Stříšovský: Structural Mechanism of Rhomboid Intramembrane Proteases and its Implications
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9:40 |
Lisa Münter: Rhomboid Protease RHBDL4 in Energy Metabolism
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10:00 |
Harald Steiner: Exosite Interactions as Targets for Substrate-Selective γ-Secretase Inhibition
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10:20 |
Stephan Breimann: Substrate-Defining Features of γ-Secretase Revealed by Comparative Physicochemical Profiling and Explainable AI |
10:35 – 11:10 Coffee break
11:10 - 13:00 Session 4: Mechanisms in Intramembrane Proteolysis II
Chair: Stefan Lichtenthaler
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11:10 |
Christina Scharnagl: Exosite-Dependent Recognition by γ-Secretase
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11:30 |
Dieter Langosch: Role of Transmembrane Domains in Intramembrane Proteolysis by γ-Secretase
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11:50 |
Claudia Muhle-Goll: Conformational Restriction in Substrate Transmembrane Domains?
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12:10 |
Franz Hagn: Investigating Structural and Dynamical Features of Membrane Protein Functionality in a Native Environment
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12:25 |
Martin Zacharias: Studying γ-Secretase Function by Molecular Dynamics Simulations
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12:45 |
Yinglong Miao: Mechanisms of γ-Secretase Activation and Processive Proteolysis of Amyloid Precursor Protein |
13:00 – 16:00 Lunch & Recreation
16:00 – 16:30 Coffee break
16:30 - 17:50 Session 5: Mechanisms in Intramembrane Proteolysis III
Chair: Claudia-Muhle-Goll
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16:30 |
Matthew Freeman: Searching for Substrates: What Do Rhomboid Proteases Really Do in Humans?
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16:50 |
Daniel Huster: Rhomboid-Catalyzed Intramembrane Proteolysis Requires Hydrophobic Matching with the Surrounding Lipid Bilayer
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17:10 |
Adam Lange: Studying Structure, Dynamics, and Inhibition of Intramembrane Proteases in a Native-Like Environment by Solid-State NMR
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17:30 |
Friedrich Förster: The First Cut Is the Deepest – Structural Insights into Signal Peptide Cleavage in the ER
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19:00 Dinner
20:30 Poster Session II (No. 15 - 27, presenters last names M-W)
Friday, May 6, 2022:
9:00 Keynote Lecture
Chair: Marius Lemberg
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9:00 |
Thomas Langer: Proteolytic Control of Mitochondrial Membrane Homeostasis |
9:45 - 10:45 Session 6: Membrane Protein Quality Control I
Chair: Dieter Langosch
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9:45 |
Sonya Neal: The Role of Rhomboid Pseudoprotease Derlins in Resolving Misfolded Protein Stress
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10:05 |
Pedro Carvalho: The Derlin Dfm1 Promotes Retrotranslocation of Folded Protein Domains from the ER
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10:25 |
Alexander Stein: Membrane Protein Retrotranslocaction during ER Associated Protein Degradation (ERAD) |
10:45 – 11:30 Coffee break
11:30 - 12:45 Session 7: Membrane Protein Quality Control II
Chair: Martin Zacharias
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11:30 |
Susan Shao: The P5A-ATPase Protects Misoriented Proteins from ERAD
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11:50 |
Matthias Feige: Intra-Membrane Client Recognition by the Molecular Chaperone Calnexin
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12:10 |
Christoph Kaether: YIPF5 and GOT1A/B are Part of a Stress Sensor Controlling ER Export
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12:25 |
Marius Lemberg: The Human Signal Peptidase Complex Serves as a Quality Control Enzyme for Membrane Proteins |
12:45 Closing Remarks: Harald Steiner & Marius Lemberg
13:00 Lunch & Departure
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