Protein Recognition and Processing

in the Membrane



2nd International Meeting 2022

of the DFG research unit FOR2290

'Understanding Intramembrane Proteolysis'

May 4-6, 2022, Munich, Germany

Wednesday, May 4, 2022:


 

13:00                Check-in & Registration

 

14:00                Welcome Notes: Dieter Langosch

 

 

14:15                Keynote Lecture

 

      Chair: Harald Steiner

 

14:15

Lucía ChávezGutiérrez: Decoding γ-Secretases and their Roles in Alzheimer’s

Pathogenesis

 

 

15:00 - 16:00    Session 1: Physiology of Regulated Intramembrane Proteolysis I

 

      Chair: Walter Stöcker

 

15:00

Christian Haass / Kai Schlepckow: Identification of TREM2 Cleavage

Sites and their Role in Alzheimer’s Disease

 

15:20

Stefan Rose-John: ADAM17 in Autoimmunity and Cancer

 

15:40

Irit Sagi: Newly Discovered Natural Anti-MT1MMP Human Antibodies

Derived from Cancer Patients

 

 

16:00-16:30      Coffee break

 

 

16:30 - 18:00    Session 2: Physiology of Regulated Intramembrane Proteolysis II

 

      Chair: Regina Fluhrer

 

16:30

Stefan Lichtenthaler: Naturally Short Substrates of γ-Secretase

 

16:50

Wim Annaert: On the Origin of Endolysosomal Dysfunction in

Presenilin/γ-Secretase Deficient Cells

 

17:10

Bernd Schröder: Signal Peptide Peptidase-Like Intramembrane

Proteases – from Immune Cells to Metabolic Regulation

 

 

17:30                Poster Lightning Talks

 

19:00               Dinner

 

 

20:30               Poster Session I (No. 1 - 14; presenters last name A-K)

 

Thursday, May 5, 2022:


 

 

09:00 - 10:35    Session 3: Mechanisms in Intramembrane Proteolysis I

 

      Chair: Daniel Huster

 

  9:00

Regina Fluhrer: Determinants of SPP/SPPL Substrates

 

  9:20

Kvido Stříšovský: Structural Mechanism of Rhomboid Intramembrane Proteases and its

Implications

 

  9:40

Lisa Münter: Rhomboid Protease RHBDL4 in Energy Metabolism

 

 10:00

Harald Steiner: Exosite Interactions as Targets for Substrate-Selective γ-Secretase

Inhibition

 

 10:20

Stephan Breimann: Substrate-Defining Features of γ-Secretase Revealed by

Comparative Physicochemical Profiling and Explainable AI

 

10:35 – 11:10   Coffee break

 

11:10 - 13:00    Session 4: Mechanisms in Intramembrane Proteolysis II

 

      Chair: Stefan Lichtenthaler

 

11:10

Christina Scharnagl: Exosite-Dependent Recognition by γ-Secretase

 

11:30

Dieter Langosch: Role of Transmembrane Domains in Intramembrane Proteolysis by γ-Secretase

 

11:50

Claudia Muhle-Goll: Conformational Restriction in Substrate Transmembrane Domains?

 

12:10

Franz Hagn: Investigating Structural and Dynamical Features of Membrane Protein

Functionality in a Native Environment

 

12:25

Martin Zacharias: Studying γ-Secretase Function by Molecular Dynamics Simulations

 

12:45

Yinglong Miao: Mechanisms of γ-Secretase Activation and Processive Proteolysis of

Amyloid Precursor Protein

 

13:00 – 16:00   Lunch & Recreation

 

16:00 – 16:30   Coffee break

 

16:30 - 17:50    Session 5: Mechanisms in Intramembrane Proteolysis III

 

      Chair: Claudia-Muhle-Goll

 

16:30

Matthew Freeman: Searching for Substrates: What Do Rhomboid Proteases Really Do in

Humans?

 

16:50

Daniel Huster: Rhomboid-Catalyzed Intramembrane Proteolysis Requires Hydrophobic

Matching with the Surrounding Lipid Bilayer

 

17:10

Adam Lange: Studying Structure, Dynamics, and Inhibition of Intramembrane Proteases in

a Native-Like Environment by Solid-State NMR

 

17:30

Friedrich Förster: The First Cut Is the Deepest – Structural Insights into Signal Peptide

Cleavage in the ER

 

 

19:00                Dinner

 

20:30                Poster Session II (No. 15 - 27, presenters last names M-W)

 

Friday, May 6, 2022:


 

 

9:00                  Keynote Lecture

 

      Chair: Marius Lemberg

 

9:00

Thomas Langer: Proteolytic Control of Mitochondrial Membrane Homeostasis

 

 

 

 9:45 - 10:45     Session 6: Membrane Protein Quality Control I

 

      Chair: Dieter Langosch

 

 9:45

Sonya Neal: The Role of Rhomboid Pseudoprotease Derlins in Resolving Misfolded Protein Stress

 

10:05

Pedro Carvalho: The Derlin Dfm1 Promotes Retrotranslocation of Folded Protein Domains from the ER

 

10:25

Alexander Stein: Membrane Protein Retrotranslocaction during ER Associated Protein Degradation (ERAD)

 

10:45 – 11:30   Coffee break

 

11:30 - 12:45    Session 7: Membrane Protein Quality Control II

 

      Chair: Martin Zacharias

 

11:30

Susan Shao: The P5A-ATPase Protects Misoriented Proteins from ERAD

 

11:50

Matthias Feige: Intra-Membrane Client Recognition by the Molecular Chaperone Calnexin

 

12:10

Christoph Kaether: YIPF5 and GOT1A/B are Part of a Stress Sensor Controlling ER Export

 

12:25

Marius Lemberg: The Human Signal Peptidase Complex Serves as a Quality Control Enzyme for

Membrane Proteins

 

12:45                Closing Remarks: Harald Steiner & Marius Lemberg

 

13:00                Lunch & Departure

 


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Research Unit FOR 2290