Protein Recognition and Processing

in the Membrane

2nd International Meeting 2022

of the DFG research unit FOR2290

'Understanding Intramembrane Proteolysis'

May 4-6, 2022, Munich, Germany

Protein Recognition and Processing in the Membrane


Protein homeostasis is fundamentally important to match the cellular needs and to counteract stress conditions. A fundamental challenge in protein homeostasis is to understand how membrane proteins are specifically recognized and processed in the hydrophobic plane of the lipid bilayer. These are unique events within the membrane environments of biological cells.


Within this context, the main focus of our meeting will be on intramembrane proteases, which are unusual enzymes with key cellular functions ranging from transcriptional control, protein maturation to regulated protein degradation. When these universal processes are deregulated, this can lead to disorders such as Alzheimer’s disease.


The common functional denominator of intramembrane proteases is cleavage within the plane of the membrane, which usually results in peptide bond scission within the transmembrane helices of their substrates. One of the prime questions in the field is how intramembrane proteases distinguish between their substrates and non-substrates. Here, recent progress started to reveal principles of how the conformational flexibility of transmembrane segments is used to sample the transmembrane domain. Strikingly, parallels to other factors ensuring membrane protein homeostasis including non-catalytic intramembrane protease variants emerge. Therefore, the meeting will also address common issues in membrane protein quality control from functional and structural perspectives.



Wednesday, May 4th: Physiology of Regulated Intramembrane Proteolysis


Thursday, May 5th: Mechanisms in Intramembrane Proteolysis


Friday, May 6th: Membrane Protein Quality Control




Lucìa Chávez‐Gutiérrez

VIB Center for Brain and Disease Research & KU Leuven




Thomas Langer
Max Planck Institute for Biology of Ageing, Cologne

Confirmed Speakers


Wim Annaert

VIB Center for Brain and Disease Research & KU Leuven


Pedro Carvalho

University of Oxford


Mattias Feige

Technical University of Munich


Regina Fluhrer

Augsburg University


Mattew Freeman

University of Oxford


Friedrich Förster

Utrecht University


Christian Haass

Ludwig Maximilian University Munich


Daniel Huster

University of Leipzig


Adam Lange

Leibniz Institute for Molecular Pharmacology, Berlin


Dieter Langosch

Technical University of Munich


Marius Lemberg

University of Cologne


Stefan Lichtenthaler

Technical University of Munich



Claudia Muhle-Goll

Karlsruhe Institute of Technology


Lisa Münter
McGill University, Montreal


Sonya Neal

University of California San Diego


Stefan Rose-John

University of Kiel


Irit Sagi

Weizmann Institute, Rehovot


Christina Scharnagl

Technical University of Munich


Bernd Schröder

University of Kiel


Susan Shao

Harvard Medical School


Alexander Stein

Max Planck Institute for Biophysical Chemistry, Göttingen


Harald Steiner

Ludwig Maximilian University Munich


Kvido Stříšovský

Academy of Sciences of the Czech Republic, Prague


Martin Zacharias

Technical University of Munich

Venue & Accommodation

IHK Academy

Feldkirchen-Westerham, near Munich, Germany


Von-Andrian-Str. 5

83620 Feldkirchen-Westerham

www: IHK Academy Westerham


Research Unit FOR 2290