Protein Recognition and Processing

in the Membrane



2nd International Meeting 2022

of the DFG research unit FOR2290

'Understanding Intramembrane Proteolysis'

May 4-6, 2022, Munich, Germany

Registration start: September 2021

Registration & Abstract Submission

Protein Recognition and Processing in the Membrane


 

Protein homeostasis is fundamentally important to match the cellular needs and to counteract stress conditions. A fundamental challenge in protein homeostasis is to understand how membrane proteins are specifically recognized and processed in the hydrophobic plane of the lipid bilayer. These are unique events within the membrane environments of biological cells.

 

Within this context, the main focus of our meeting will be on intramembrane proteases, which are unusual enzymes with key cellular functions ranging from transcriptional control, protein maturation to regulated protein degradation. When these universal processes are deregulated, this can lead to disorders such as Alzheimer’s disease.

 

The common functional denominator of intramembrane proteases is cleavage within the plane of the membrane, which usually results in peptide bond scission within the transmembrane helices of their substrates. One of the prime questions in the field is how intramembrane proteases distinguish between their substrates and non-substrates. Here, recent progress started to reveal principles of how the conformational flexibility of transmembrane segments is used to sample the transmembrane domain. Strikingly, parallels to other factors ensuring membrane protein homeostasis including non-catalytic intramembrane protease variants emerge. Therefore, the meeting will also address common issues in membrane protein quality control from functional and structural perspectives.

 

 

Wednesday, May 4th: Physiology of Regulated Intramembrane Proteolysis

 

Thursday, May 5th: Mechanisms in Intramembrane Proteolysis

 

Friday, May 6th: Membrane Protein Quality Control

 

Keynote


 

Lucìa Chávez‐Gutiérrez

VIB Center for Brain and Disease Research & KU Leuven

 

 

 

Ramanujan Hedge

MRC Laboratory of Molecular Biology, Cambridge

 


Confirmed Speakers


 

Wim Annert

VIB Center for Brain and Disease Research & KU Leuven

 

Mattias Feige

Technical University of Munich

 

Regina Fluhrer

Augsburg University

 

Mattew Freeman

University of Oxford

 

Friedrich Förster

Utrecht University

 

Christian Haass

Ludwig Maximilian University Munich

 

Daniel Huster

University of Leipzig

 

Adam Lange

Leibniz Institute for Molecular Pharmacology, Berlin

 

Thomas Langer
Max Planck Institute for Biology of Ageing, Cologne

 

Dieter Langosch

Technical University of Munich

 

Marius Lemberg

University of Cologne

 

Stefan Lichtenthaler

Technical University of Munich

 

 

Claudia Muhle-Goll

Karlsruhe Institute of Technology

 

Lisa Münter
McGill University, Montreal

 

Sonja Neal

University of California San Diego

 

Stefan Rose-John

University of Kiel

 

Irit Sagi

Weizmann Institute, Rehovot

 

Christina Scharnagl

Technical University of Munich

 

Bernd Schröder

University of Kiel

 

Sichen Shao

Harvard Medical School

 

Alexander Stein

Max Planck Institute for Biophysical Chemistry, Göttingen

 

Harald Steiner

Ludwig Maximilian University Munich

 

Kvido Stříšovský

Academy of Sciences of the Czech Republic, Prague

 

Martin Zacharias

Technical University of Munich


Venue & Accommodation


IHK Academy

Feldkirchen-Westerham, near Munich, Germany

 

Von-Andrian-Str. 5

83620 Feldkirchen-Westerham

www: IHK Academy Westerham

 



Research Unit FOR 2290