Protein Recognition and Processing
in the Membrane
of the DFG research unit FOR2290
'Understanding Intramembrane Proteolysis'
May 4-6, 2022, Munich, Germany
Protein Recognition and Processing in the Membrane
Protein homeostasis is fundamentally important to match the cellular needs and to counteract stress conditions. A fundamental challenge in protein homeostasis is to understand how membrane proteins are specifically recognized and processed in the hydrophobic plane of the lipid bilayer. These are unique events within the membrane environments of biological cells.
Within this context, the main focus of our meeting will be on intramembrane proteases, which are unusual enzymes with key cellular functions ranging from transcriptional control, protein maturation to regulated protein degradation. When these universal processes are deregulated, this can lead to disorders such as Alzheimer’s disease.
The common functional denominator of intramembrane proteases is cleavage within the plane of the membrane, which usually results in peptide bond scission within the transmembrane helices of their substrates. One of the prime questions in the field is how intramembrane proteases distinguish between their substrates and non-substrates. Here, recent progress started to reveal principles of how the conformational flexibility of transmembrane segments is used to sample the transmembrane domain. Strikingly, parallels to other factors ensuring membrane protein homeostasis including non-catalytic intramembrane protease variants emerge. Therefore, the meeting will also address common issues in membrane protein quality control from functional and structural perspectives.
Wednesday, May 4th: Physiology of Regulated Intramembrane Proteolysis
Thursday, May 5th: Mechanisms in Intramembrane Proteolysis
Friday, May 6th: Membrane Protein Quality Control
Lucìa Chávez‐Gutiérrez
VIB Center for Brain and Disease Research & KU Leuven
Thomas Langer
Max Planck Institute for Biology of Ageing, Cologne
Wim Annaert
VIB Center for Brain and Disease Research & KU Leuven
Pedro Carvalho
University of Oxford
Mattias Feige
Technical University of Munich
Regina Fluhrer
Augsburg University
Mattew Freeman
University of Oxford
Friedrich Förster
Utrecht University
Christian Haass
Ludwig Maximilian University Munich
Daniel Huster
University of Leipzig
Adam Lange
Leibniz Institute for Molecular Pharmacology, Berlin
Dieter Langosch
Technical University of Munich
Marius Lemberg
University of Cologne
Stefan Lichtenthaler
Technical University of Munich
Claudia Muhle-Goll
Karlsruhe Institute of Technology
Lisa Münter
McGill University, Montreal
Sonya Neal
University of California San Diego
Stefan Rose-John
University of Kiel
Irit Sagi
Weizmann Institute, Rehovot
Christina Scharnagl
Technical University of Munich
Bernd Schröder
University of Kiel
Susan Shao
Harvard Medical School
Alexander Stein
Max Planck Institute for Biophysical Chemistry, Göttingen
Harald Steiner
Ludwig Maximilian University Munich
Kvido Stříšovský
Academy of Sciences of the Czech Republic, Prague
Martin Zacharias
Technical University of Munich
IHK Academy
Feldkirchen-Westerham, near Munich, Germany
Von-Andrian-Str. 5
83620 Feldkirchen-Westerham